CTG Trinucleotide Repeat “Big Jumps”: Large Expansions, Small Mice
نویسندگان
چکیده
منابع مشابه
CTG Trinucleotide Repeat “Big Jumps”: Large Expansions, Small Mice
Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1. Disease severity and age of onset are critically linked to expansion size. Previous mouse models of repeat instability have not recreated large intergenerational expansions ("big jumps"), observed when the repeat is transmit...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2007
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.0030052